Mitochondrial cascade hypothesis

Abstract

The pathogenesis of AD is discussed through mitochondrial cascade hypothesis, where mitochondrial dysfunction, energy imbalance, and cellular stress may lead to neuronal damage and cognitive decline. Mitochondrial dysfunction accelerates ATP deficiency and the accumulation of reactive oxygen species, which puts neurons under severe stress and leads to their death. Therefore, improving mitochondrial function and reducing cellular stress are important directions in the future treatment of Alzheimer's.